The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 08, 2018
Filed:
Jul. 12, 2013
Menicon Co., Ltd., Nagoya-shi, JP;
Hidenori Yokoi, Kasugai, JP;
Yasuhiro Yokoyama, Kasugai, JP;
Keisuke Matsuyama, Kobe, JP;
Kenichiro Yamamoto, Tatsuno, JP;
Kinsei Anzai, Osaka, JP;
Daisuke Nakamura, Tatsuno, JP;
Toyohiro Nagano, Tatsuno, JP;
Kazuya Kodama, Tatsuno, JP;
MENICON CO., LTD., Nagoya-Shi, JP;
Abstract
An object of the present invention is to provide a process capable of producing a self-assembling peptide derivative that is useful in the fields of regenerative medicine and surgery in large quantities and in an economical and efficient manner. In particular, provided is a production process employing a combination of (i) a step of convergently constructing a sequence with use of a common repeating unit consisting of a specific amino acid sequence and (ii) a step of first isolating the peptide derivative as a disulfuric acid salt, a tetramethanesulfonic acid salt or a tetra(trifluoroacetic acid (TFA) salt), and then subjecting the peptide salt to a salt exchange reaction to yield a tetrahydrochloric acid salt.