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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9963452 B1

PDFFull Text
Date of Patent:
May. 08, 2018

Filed:

Mar. 13, 2014

Methods, compounds, and compositions for inhibition of ros

Applicants:

Dorre A. Grueneberg, Newton, MA (US);

Ori Kalid, Pardes-Hanna, IL;

Jun Xian, Sharon, MA (US);

Sharanappa B. Rajur, Andover, MA (US);

Hwa-ok Kim, Lexington, MA (US);

Venugopal Rao Neelagiri, Acton, MA (US);

Paresh Salgaonkar, Medford, MA (US);

Divakaramenon Sethumadhavan, Waltham, MA (US);

Chaeho Moon, Burlington, MA (US);

Madhavi Neelagiri, Acton, MA (US);

Inventors:

Dorre A. Grueneberg, Newton, MA (US);

Ori Kalid, Pardes-Hanna, IL;

Jun Xian, Sharon, MA (US);

Sharanappa B. Rajur, Andover, MA (US);

Hwa-Ok Kim, Lexington, MA (US);

Venugopal Rao Neelagiri, Acton, MA (US);

Paresh Salgaonkar, Medford, MA (US);

Divakaramenon Sethumadhavan, Waltham, MA (US);

Chaeho Moon, Burlington, MA (US);

Madhavi Neelagiri, Acton, MA (US);

Assignee:

AUGUSTA PHARMACEUTICALS INC., Newton, MA (US);

Attorney:

Gearhart Law LLC

Primary Examiner:

Shengjun Wang

Int. Cl.
CPC ...
A61K 31/505 (2006.01); A61K 31/53 (2006.01); C07D 487/04 (2006.01); A61K 45/06 (2006.01); A61K 31/404 (2006.01); A61K 31/4375 (2006.01); A61K 31/454 (2006.01); A61K 31/497 (2006.01); A61K 31/506 (2006.01); A61K 31/519 (2006.01); A61K 31/551 (2006.01); C07D 209/08 (2006.01); C07D 243/14 (2006.01); C07D 401/14 (2006.01); C07D 403/12 (2006.01); C07D 409/14 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); A61K 31/194 (2006.01); A61K 31/437 (2006.01); A61K 31/452 (2006.01); A61K 31/4545 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/194 (2013.01); A61K 31/404 (2013.01); A61K 31/437 (2013.01); A61K 31/4375 (2013.01); A61K 31/452 (2013.01); A61K 31/454 (2013.01); A61K 31/4545 (2013.01); A61K 31/497 (2013.01); A61K 31/506 (2013.01); A61K 31/519 (2013.01); A61K 31/53 (2013.01); A61K 31/551 (2013.01); A61K 45/06 (2013.01); C07D 209/08 (2013.01); C07D 243/14 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 409/14 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01);
Abstract

The present invention relates to a method using some novel compounds and compositions for the inhibition of ROS tyrosine kinase. In particular, the present invention covers a method to treat abnormal cell growth, such as cancer, with ROSinhibitors and compositions having ROS inhibitors. An illustrative compound of the invention is shown below Formula (I).

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