The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 08, 2018
Filed:
Aug. 20, 2014
University of Washington Through Its Center for Commercialization, Seattle, WA (US);
University of Montana, Missoula, MT (US);
Philippe Diaz, Missoula, MT (US);
Nina Isoherranen, Seattle, WA (US);
Brian Buttrick, Seattle, WA (US);
Nicolas Guilloteau, Missoula, MT (US);
University of Washington Through Its Center For Commercialization, Seattle, WA (US);
University of Montana, Missoula, MT (US);
Abstract
The present disclosure is generally directed to compositions and methods for treating diseases that are ameliorated by the inhibition of CYP26 mediated retinoic acid metabolism. The compositions comprise compounds of formula (I). A repreid50000060307390 IB/345 nullsents aryl optionally substituted with one, two, three, or four groups that are each independently halogen, cyano, nitro, Calkyl, Chaloalkyl, —NH, —NH(C-Calkyl), —N(C-Calkyl), —OH, C-Calkoxy, and C-Chaloalkoxy; X is a bond, —CH—, —CHR—, —C═CHR—, —NR—, —N═O—R—, —O—, —S—, —SO—, —SO—, —C(O)—, or —C(NR)—, or X is of formula (a), (b) or (c), wherein each n is independently 1, 2, or 3; each Ris independently hydrogen or Calkyl; Ris independently hydrogen, Calkyl, or —OR, where Ris selected from the group consisting of hydrogen, Calkyl, Calkenyl, CalkynyL Ccycloalkyl, heterocyclyl, aryl, arylCalkyl, heteroaryl, or heteroarylCalkyl; Y is Calkylene, Calkenylene, or Calkylylene moiety.