The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 01, 2018
Filed:
Oct. 23, 2013
Caris Life Sciences Switzerland Holdings, S.a.r.l., Basel, CH;
David Halbert, Colleyville, TX (US);
Valeriy Domenyuk, Tempe, AZ (US);
David Spetzler, Paradise Valley, AZ (US);
Tassilo Hornung, Tempe, AZ (US);
Frank Schafer, Düsseldorf, DE;
Nianqing Xiao, Rockville, MD (US);
Caris Life Sciences Switzerland Holdings GMBH, Basel, CH;
Abstract
Methods and compositions are provided for specific aptamers and aptamer pools that bind biomarkers of interest such as microvesicle surface antigens or functional fragments of microvesicle surface antigens. In various embodiments, aptamers of the invention are used in diagnostic, prognostic, or theranostic processes to screen a biological sample for the presence or levels of biomarkers such as microvesicles that are determined to provide a diagnostic, prognostic, or theranostic readout. The diagnosis, prognosis, or theranosis may be related to cancer or other diseases and disorders. The invention also provides methods and composition to facilitate aptamer library screening and aptamer detection methods.