The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 01, 2018
Filed:
Apr. 18, 2013
Applicants:
Vib Vzw, Ghent, BE;
Katholieke Universiteit Leuven, K.u.leuven R&d, Leuven, BE;
Inventors:
Frederic Rousseau, Groot-Bijgaarden, BE;
Joost Schymkowitz, Meensel-Kiezegem, BE;
Ashok Ganesan, Tiruvannamalai, IN;
Aleksandra Siekierska, Brussels, BE;
Frederik De Smet, Winksele, BE;
Joost Van Durme, Wakken, BE;
Assignees:
VIB VZW, Ghent, BE;
KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D, Leuven, BE;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 9/24 (2006.01); C07K 14/43 (2006.01); G06F 19/16 (2011.01); C07K 14/32 (2006.01); C40B 30/02 (2006.01); C12N 9/40 (2006.01); C07K 14/435 (2006.01);
U.S. Cl.
CPC ...
C12N 9/2465 (2013.01); C07K 14/32 (2013.01); C07K 14/43595 (2013.01); C40B 30/02 (2013.01); G06F 19/16 (2013.01);
Abstract
The disclosure provides a general method for the production of protein variants with a reduced aggregation propensity without affecting the thermodynamic stability of the variant with respect to the wild-type protein.