The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 01, 2018
Filed:
Feb. 07, 2014
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Washington, DC (US);
The Research Foundation for the State University of New York, Albany, NY (US);
Peter L. Collins, Silver Spring, MD (US);
Cyril Le Nouën, Bethesda, MD (US);
Linda G. Brock, Bethesda, MD (US);
Ursula J. Buchholz, Silver Spring, MD (US);
Joshua Marc DiNapoli, Lexington, MA (US);
Steffen Mueller, Kings Point, NY (US);
Eckard Wimmer, E. Setauket, NY (US);
The United States of America, as represented by the Secretary, Dept. of Health and Human Services, Washington, DC (US);
The Research Foundation For the State University of New York, Albany, NY (US);
Abstract
Described herein are RSV polynucleotide sequences that make use of multiple codons that are containing silent nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce a numerous synonymous codons into the genome. Due to the large number of defects involved, the attenuated viruses disclosed herein provide a means of producing attenuated, live vaccines against RSV.