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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9957293 B1

PDFFull Text
Date of Patent:
May. 01, 2018

Filed:

Apr. 16, 2012

Conjugates of rgd peptides and porphyrin or (bacterio)chlorophyll photosynthesizers and their uses

Applicants:

Avigdor Scherz, Rehovot, IL;

Yoram Salomon, Rehovot, IL;

Efrat Rubinstein, Rehovot, IL;

Alexander Brandis, Rehovot, IL;

Doron Eren, Rehovot, IL;

Karin Neimann, Rehovot, IL;

Inventors:

Avigdor Scherz, Rehovot, IL;

Yoram Salomon, Rehovot, IL;

Efrat Rubinstein, Rehovot, IL;

Alexander Brandis, Rehovot, IL;

Doron Eren, Rehovot, IL;

Karin Neimann, Rehovot, IL;

Assignee:

YEDA RESEARCH AND DEVELOPMENT COMPANY LTD., Rehovot, IL;

Attorney:

Browdy and Neimark, PLLC

Primary Examiner:

Michael G Hartley

Assistant Examiner:

Melissa J Perreira

Int. Cl.
CPC ...
C07K 5/12 (2006.01); C07K 5/09 (2006.01); C07K 5/10 (2006.01); C07K 7/06 (2006.01); C07K 7/64 (2006.01); A61K 41/00 (2006.01); A61K 51/08 (2006.01); G01N 33/574 (2006.01); A61K 47/64 (2017.01); A61K 51/00 (2006.01); A61M 36/14 (2006.01);
U.S. Cl.
CPC ...
C07K 5/123 (2013.01); A61K 41/0071 (2013.01); A61K 47/64 (2017.08); A61K 51/082 (2013.01); A61K 51/088 (2013.01); C07K 5/0817 (2013.01); C07K 5/10 (2013.01); C07K 5/126 (2013.01); C07K 7/06 (2013.01); C07K 7/64 (2013.01); G01N 33/57426 (2013.01); A61K 41/00 (2013.01); G01N 2333/96411 (2013.01);
Abstract

Conjugates of porphyrin, chlorophyll and bacteriochlorophyll photosensitizers with RGD-containing peptides or RGD peptidomimetics are provided that are useful for photodynamic therapy (PDT), particularly vascular-targeted PDT (VTP), of tumors and nonneoplastic vascular diseases such as age-related macular degeneration, and for diagnosis of tumors by different techniques.

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