The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 01, 2018
Filed:
Oct. 02, 2015
Ustav Experimentalni Botaniky Av Cr, V.v.i., Prague, CZ;
Libor Havlicek, Prague, CZ;
Antonin Sturc, Prague, CZ;
Vladimir Krystof, Olomouc, CZ;
Radek Jorda, Olomouc, CZ;
Tomas Pospisil, Olomouc, CZ;
Stefan Zahler, Maisach, DE;
Angelika Vollmar, Pullach, DE;
Miroslav Strnad, Olomouc, CZ;
USTAV EXPERIMENTALNI BOTANIKY AV CR, V.V.I., Prague, CZ;
Abstract
5-substituted-7-[4-(2-pyridyl)phenylmethylamino]-3-isopropylpyrazolo[4,3-d]pyrimidines are potent inhibitors of protein kinases, especially cyclin-dependent kinases such as CDK2 and CDK5, and display antileukemic, pro-apoptotic, antiangiogenic and anticancer activities. The invention also relates to processes for their preparation, to pharmaceutical compositions and to their use as medicaments, particularly in the treatment of disorders involving cell proliferation, apoptosis, angiogenesis and inflammation, such as leukemia and metastatic solid cancer.