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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9957270 B1

PDFFull Text
Date of Patent:
May. 01, 2018

Filed:

Mar. 13, 2015

Fused pyrimidine-based hydroxamate derivatives

Applicant:

Agency for Science, Technology and Research, Singapore, SG;

Inventors:

Haishan Wang, Singapore, SG;

Dizhong Chen, Singapore, SG;

Chang Kai Soh, Singapore, SG;

Assignee:

AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH, Singapore, SG;

Attorney:

Choate, Hall & Stewart LLP

Primary Examiner:

Jeffrey H Murray

Int. Cl.
CPC ...
A01N 43/90 (2006.01); A61K 31/52 (2006.01); A61K 31/519 (2006.01); C07D 473/00 (2006.01); C07D 487/00 (2006.01); C07D 473/34 (2006.01); C07D 473/32 (2006.01); A61K 45/06 (2006.01); A61K 31/5377 (2006.01); C07D 473/16 (2006.01); C07D 473/40 (2006.01);
U.S. Cl.
CPC ...
C07D 473/34 (2013.01); A61K 31/52 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); C07D 473/16 (2013.01); C07D 473/32 (2013.01); C07D 473/40 (2013.01);
Abstract

The present invention relates to fused pyrimidine-based hydroxamate compounds of formula (I), comprising a hydroxamate group, that are inhibitors of histone deacetylase (HDAC) and kinases. More particularly, the present invention relates to hydroxamate substituted purine or 5H-pyrrolo[3,2-d]pyrimidine derivatives, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of disorders/conditions/diseases involving, relating to or associated with enzymes having histone deacetylase, non-histone deacetylase and kinase activities/functions and/or via unspecified/multi-targeted mechanisms.

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