The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 01, 2018

Filed:

Dec. 20, 2013
Applicant:

Universite DE Droit ET DE LA Sante DE Lille 2, Lille, FR;

Inventors:

Nicolas Willand, Lille, FR;

Benoit Deprez, Lille, FR;

Alain Baulard, Tournai, BE;

Priscille Brodin, Paris, FR;

Marion Flipo, Lille, FR;

Lucie Maingot, Cambridgeshire, GB;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/04 (2006.01); C07D 295/185 (2006.01); C07D 211/16 (2006.01); C07D 211/18 (2006.01); C07D 211/22 (2006.01); C07D 207/08 (2006.01); A61K 31/40 (2006.01); A61K 31/451 (2006.01); A61K 31/4545 (2006.01); A61K 31/495 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 401/04 (2013.01); A61K 31/40 (2013.01); A61K 31/451 (2013.01); A61K 31/4545 (2013.01); A61K 31/495 (2013.01); A61K 45/06 (2013.01); C07D 207/08 (2013.01); C07D 211/16 (2013.01); C07D 211/18 (2013.01); C07D 211/22 (2013.01); C07D 295/185 (2013.01);
Abstract

The present invention concerns a compound of general formula (I): in which n=0 or 1, R1 represents an optionally substituted alkyl chain, in particular substituted alkyl chain, in particular substituted with fluorine, X is chosen from N and CH, and R2 is chosen from optionally substituted phenyl and benzyl, wherein the heterocycles having 6 vertices comprise one, two or three nitrogen atoms. The present invention also concerns the use of this compound as a medicament, in particular in the treatment of bacterial and mycobacterial infections such as tuberculosis in combination with an antibiotic that is active against bacteria and/or mycobacteria, said compound potentiating the activity of said antibiotic.


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