The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 01, 2018
Filed:
Nov. 02, 2015
The General Hospital Corporation, Boston, MA (US);
Gpb Scientific, Llc, Richmond, VA (US);
Lotien Richard Huang, Chestnut Hill, MA (US);
Thomas A. Barber, Allston, MA (US);
Bruce L. Carvalho, Watertown, MA (US);
Ravi Kapur, Sharon, MA (US);
Paul Vernucci, Billerica, MA (US);
Mehmet Toner, Charlestown, MA (US);
Zihua Wang, Newton, MA (US);
The General Hospital Corporation, Boston, MA (US);
GPB Scientific, LLC, Richmond, VA (US);
Abstract
The invention features devices and methods for the deterministic separation of particles. Exemplary methods include the enrichment of a sample in a desired particle or the alteration of a desired particle in the device. The devices and methods are advantageously employed to enrich for rare cells, e.g., fetal cells, present in a sample, e.g., maternal blood and rare cell components, e.g., fetal cell nuclei. The invention further provides a method for preferentially lysing cells of interest in a sample, e.g., to extract clinical information from a cellular component, e.g., a nucleus, of the cells of interest. In general, the method employs differential lysis between the cells of interest and other cells (e.g., other nucleated cells) in the sample.