The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 01, 2018
Filed:
Jun. 05, 2013
Georgia State University Research Foundation, Inc., Atlanta, GA (US);
Jenny Jie Yang, Marietta, GA (US);
Zhiren Liu, Atlanta, GA (US);
Shunyi Li, Wuhan, CN;
Yubin Zhou, Houston, TX (US);
Jie Jiang, Atlanta, GA (US);
Shenghui Xue, Atlanta, GA (US);
Jingjuan Qiao, Atlanta, GA (US);
Lixia Wei, Duluth, GA (US);
Georgia State University Research Foundation, Inc., Atlanta, GA (US);
Abstract
Provided is a protein contrast agent for enhancing an MRI image and comprising a polypeptide having a conformation presenting at least five oxygen atoms positioned to chelate at least one paramagnetic metal ion such as Gd, each oxygen atom being between about 2 angstrom units and about 5 angstrom units from the metal ion; the metal ion has at least one water molecule electrostatically interacting a distance of less than about 10 angstrom units a target-specific moiety conjugated thereto, at least one polyethylene glycol molecule, and a paramagnetic metal ion. Also provided is a method of obtaining an enhanced MRI image using the protein contrast agent to a T2/T1 or T1/T2 intensity ratio of the MRI image; and (d) obtaining an image of the T2/T1 or T1/T2 intensity ratio.