The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 01, 2018

Filed:

May. 01, 2015
Applicant:

Oncoethix Gmbh, Lucerne, CH;

Inventors:

Kay Noel, El Cerrito, CA (US);

Maria E. Riveiro, Clichy, FR;

Assignee:

OncoEthix GMBH, Lucerne, CH;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/55 (2006.01); A61K 31/551 (2006.01); A61K 31/5517 (2006.01); A61K 45/06 (2006.01); A61K 31/573 (2006.01); A61K 9/00 (2006.01); A61K 9/10 (2006.01); A61K 47/32 (2006.01); A61K 47/38 (2006.01); A61K 9/14 (2006.01); A61K 9/48 (2006.01);
U.S. Cl.
CPC ...
A61K 31/551 (2013.01); A61K 9/0019 (2013.01); A61K 9/0053 (2013.01); A61K 9/10 (2013.01); A61K 9/146 (2013.01); A61K 9/4866 (2013.01); A61K 31/5517 (2013.01); A61K 31/573 (2013.01); A61K 45/06 (2013.01); A61K 47/32 (2013.01); A61K 47/38 (2013.01); A61K 31/55 (2013.01);
Abstract

A method of treating acute myeloid leukemia, acute lymphoblastic leukemia, high risk myelodysplastic syndrome, and/or HR-MDS/AML in a mammal by administering a solid dispersion comprising an amorphous thienotriazolodiazepine compound of the Formula (1) wherein R1 is alkyl having a carbon number of 1-4, R2 is a hydrogen atom; a halogen atom; or alkyl having a carbon number of 1-4 optionally substituted by a halogen atom or a hydroxyl group, R3 is a halogen atom; phenyl optionally substituted by a halogen atom, alkyl having a carbon number of 1-4, alkoxy having a carbon number of 1-4 or cyano; —NR5-(CH2)m R6 wherein R5 is a hydrogen atom or alkyl having a carbon number of 1-4, m is an integer of 0-4, and R6 is phenyl or pyridyl optionally substituted by a halogen atom.


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