The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 24, 2018

Filed:

Oct. 10, 2014
Applicants:

Axel Visel, El Cerrito, CA (US);

John L. R. Rubenstein, San Francisco, CA (US);

Ying-jiun (Jasmine) Chen, South San Francisco, CA (US);

Len A. Pennacchio, Sebastopol, CA (US);

Daniel Vogt, Burlingame, CA (US);

Cory Nicholas, San Francisco, CA (US);

Arnold Kriegstein, Mill Valley, CA (US);

Inventors:

Axel Visel, El Cerrito, CA (US);

John L. R. Rubenstein, San Francisco, CA (US);

Ying-Jiun (Jasmine) Chen, South San Francisco, CA (US);

Len A. Pennacchio, Sebastopol, CA (US);

Daniel Vogt, Burlingame, CA (US);

Cory Nicholas, San Francisco, CA (US);

Arnold Kriegstein, Mill Valley, CA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/85 (2006.01); G01N 33/569 (2006.01); G01N 33/50 (2006.01); A61K 35/545 (2015.01); C12N 15/86 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
G01N 33/56966 (2013.01); A61K 35/545 (2013.01); C12N 15/85 (2013.01); C12N 15/86 (2013.01); G01N 33/5014 (2013.01); A61K 48/00 (2013.01); C12N 2830/008 (2013.01);
Abstract

Herein are described a set of novel specific human enhancers for specific forebrain cell types used to study and select for human neural progenitor cells. This approach enables the ability to generate interneurons from human ES, iPS and iN cells, making them available for human transplantation and for molecular/cellular analyzes. These approaches are also directly applicable to generating other neuronal cell types, such as cortical and striatal projection neurons, which have implications for many human diseases.


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