The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 24, 2018
Filed:
Dec. 18, 2015
Applicants:
Roche Molecular Systems, Inc., Pleasanton, CA (US);
The University of North Carolina AT Chapel Hill, Chapel Hill, CA (US);
Inventors:
George Martin, Berkeley, CA (US);
Steven Soper, Baton Rouge, LA (US);
Makgorzata Witek, Chapel Hill, NC (US);
Jen Jen Yeh, Chapel Hill, NC (US);
Assignees:
Roche Molecular Systems, Inc., Pleasanton, CA (US);
The University of North Carolina Chapel Hill, Chapel Hill, NC (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/543 (2006.01); G01N 33/569 (2006.01); G01N 33/574 (2006.01); G01N 33/577 (2006.01); B01L 3/00 (2006.01);
U.S. Cl.
CPC ...
G01N 33/54386 (2013.01); G01N 33/56966 (2013.01); G01N 33/577 (2013.01); G01N 33/57492 (2013.01); B01L 3/5027 (2013.01); G01N 2333/96433 (2013.01); G01N 2333/96466 (2013.01);
Abstract
This invention provides methods and compositions for capturing circulating tumor cells (CTCs) as well as various divergent CTC phenotypes using seprase-specific affinity reagents. Methods of analyzing CTCs and assessing their metastatic potential in vivo and in vitro are also disclosed.