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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9952202 B1

PDFFull Text
Expired
Date of Patent:
Apr. 24, 2018

Filed:

Mar. 07, 2014

Methods of identifying compounds for the treatment of fibrosis by using s1pr5

Applicant:

Galapagos NV, Mechelen, BE;

Inventors:

Richard Antonius Jozef Janssen, Leiden, NL;

Annemarie Nicolete Lekkerkerker, Palo Alto, CA (US);

Jamil Aarbiou, Leiden, NL;

Krista Ouwehand, Leiden, NL;

Assignee:

GALAPAGOS NV, Mechelen, BE;

Attorney:

Klauber & Jackson LLP

Primary Examiner:

Bridget E Bunner

Int. Cl.
CPC ...
G01N 33/50 (2006.01); G01N 33/53 (2006.01); G01N 33/566 (2006.01); G01N 33/68 (2006.01); C12Q 1/68 (2018.01); A01K 67/027 (2006.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01); C07K 14/705 (2006.01); G01N 24/08 (2006.01);
U.S. Cl.
CPC ...
G01N 33/5044 (2013.01); A01K 67/027 (2013.01); C12N 15/111 (2013.01); C12N 15/113 (2013.01); C12N 15/1137 (2013.01); C12N 15/1138 (2013.01); C12Q 1/6883 (2013.01); C12Y 107/01007 (2013.01); C12Y 201/01077 (2013.01); C12Y 207/01014 (2013.01); C12Y 207/01033 (2013.01); C12Y 207/04006 (2013.01); C12Y 207/08002 (2013.01); C12Y 207/11001 (2013.01); C12Y 304/22 (2013.01); G01N 33/6893 (2013.01); A01K 2207/10 (2013.01); A01K 2207/30 (2013.01); A01K 2227/105 (2013.01); A01K 2267/03 (2013.01); C07K 14/705 (2013.01); C12N 2310/12 (2013.01); C12N 2310/14 (2013.01); C12N 2310/531 (2013.01); C12N 2320/10 (2013.01); C12N 2320/12 (2013.01); C12Q 2600/158 (2013.01); G01N 24/088 (2013.01); G01N 33/50 (2013.01); G01N 33/53 (2013.01); G01N 2333/705 (2013.01); G01N 2800/085 (2013.01);
Abstract

The present invention relates to methods and assays for identifying agents useful in the treatment of fibrotic diseases, in particular diseases related to fibroblast migration and differentiation. The invention provides polypeptide and nucleic acid TARGETs, siRNA sequences based on these TARGETs and antibodies against the TARGETs. The invention is further related to pharmaceutical composition comprising siRNA sequences based on the TARGETs and antibodies against the TARGETs for use in the treatment of fibrotic disease. The invention further provides in vitro methods for inhibition of fibroblast migration and differentiation.

Find Patent Forward Citations

Janssen, Richard Antonius Jozef. (2018). Methods of identifying compounds for the treatment of fibrosis by using s1pr5 (U.S. Patent No. 9952202). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9952202

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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