The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 24, 2018

Filed:

Jul. 16, 2013
Applicant:

The Arizona Board of Regents on Behalf of the University of Arizona, Tucson, AZ (US);

Inventors:

Urs Utzinger, Tucson, AZ (US);

Bhaskar Banerjee, Tucson, AZ (US);

Timothy E. Renkoski, Tucson, AZ (US);

Nathaniel S. Rial, Tucson, AZ (US);

Logan Graves, Tucson, AZ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 21/00 (2006.01); G01N 21/64 (2006.01); A61B 1/00 (2006.01); G01N 21/47 (2006.01); G01N 21/55 (2014.01); G01N 33/483 (2006.01); A61B 1/04 (2006.01);
U.S. Cl.
CPC ...
G01N 21/6486 (2013.01); A61B 1/00009 (2013.01); G01N 21/4795 (2013.01); G01N 21/55 (2013.01); G01N 21/6456 (2013.01); G01N 33/4833 (2013.01); A61B 1/0005 (2013.01); A61B 1/043 (2013.01); G01N 21/6458 (2013.01); G01N 2021/6484 (2013.01);
Abstract

Methods for reliable identification of low-contrast lesions within a tissue of a subject comprise delivering an excitation signal to the tissue, wherein the excitation signal is selected to stimulate tissue to produce autofluorescence and/or reflectance. The autofluorescence and/or reflectance is detected, and ratiometric images are produced based on the autofluorescence and/or reflectance images. An imaging system is provided which is configured to carry out such methods, irradiating tissue at a various possible excitation wavelengths, such as UV excitation wavelengths below 300 nm, to elicit fluorescence from specific native fluorophores.


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