The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 24, 2018

Filed:

Mar. 08, 2016
Applicant:

Academia Sinica, Taipei, TW;

Inventors:

An-Suei Yang, Taipei, TW;

Yu-Ching Lee, Taipei, TW;

Ing-Chien Chen, Taipei, TW;

Chung-Ming Yu, Taipei, TW;

Hung-Ju Hsu, Taipei, TW;

Yi-Jen Huang, Taipei, TW;

Hung-Ju Chang, Taipei, TW;

Keng-Chang Tsai, Taipei, TW;

Hung-Pin Peng, Taipei, TW;

Assignee:

Academic Sinica, Taipei, TW;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C40B 40/08 (2006.01); C07K 16/00 (2006.01); C07K 16/10 (2006.01); C07K 16/22 (2006.01); C12N 15/10 (2006.01); C40B 50/06 (2006.01); C12N 15/73 (2006.01);
U.S. Cl.
CPC ...
C07K 16/005 (2013.01); C07K 16/1018 (2013.01); C07K 16/22 (2013.01); C12N 15/1037 (2013.01); C12N 15/1051 (2013.01); C12N 15/73 (2013.01); C40B 40/08 (2013.01); C40B 50/06 (2013.01); C07K 2317/622 (2013.01); C07K 2317/624 (2013.01); C07K 2319/02 (2013.01); C12N 2795/00022 (2013.01);
Abstract

Disclosed are nucleic acid libraries for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and for facilitating production of a disulfide-stabilized single chain antibody. Also disclosed are host cell libraries and phage libraries including the nucleic acid libraries. Further disclosed are methods for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and methods for producing a disulfide-stabilized single chain antibody and non-fusion form thereof.


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