The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 24, 2018
Filed:
Jun. 04, 2014
Virginia Commonwealth University, Richmond, VA (US);
Paul B. Fisher, Richmond, VA (US);
Praveen Bhoopathi, Richmond, VA (US);
Swadesh K. Das, Richmond, VA (US);
Luni Emdad, Richmond, VA (US);
Devanand Sarkar, Richmond, VA (US);
Upneet Sokhi, Richmond, VA (US);
Virginia Commonwealth University, Richmond, VA (US);
Abstract
Recombinant therapeutic cytokines ('therakines') for the treatment of cancer are provided. The recombinant therakines include a truncated region of MDA-7/TL-24 ('M4') not normally found in nature that has anti-cancer activity and a secretory signal which causes secretion of the therakine from plasmid/virus transduced normal and cancer cells and interaction of the therakine to MDA-7/IL-24 receptors on adjacent, neighboring and distant cancer cells. Therakine interaction results in bystander killing of the target cancer cell as well as adjacent, neighboring and distant cancer cells.