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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9951065 B1

PDFFull Text
Date of Patent:
Apr. 24, 2018

Filed:

May. 12, 2016

Benzimidazole and imadazopyridine carboximidamide compounds

Applicant:

Gilead Sciences, Inc., Foster City, CA (US);

Inventors:

Mark J. Bartlett, Castro Valley, CA (US);

Julian Andrew Codelli, Seattle, WA (US);

Britton Kenneth Corkey, Redwood City, CA (US);

Jennifer Leigh Cosman, Foster City, CA (US);

Kristyna Elbel, South San Francisco, CA (US);

Jennifer Alissa Loyer-Drew, Seattle, WA (US);

David Sperandio, Palo Alto, CA (US);

Joshua Van Veldhuizen, Seattle, WA (US);

Hai Yang, San Mateo, CA (US);

Suet Chung Yeung, Redmond, WA (US);

Assignee:

Gilead Sciences, Inc., Foster City, CA (US);

Attorney:
Primary Examiner:

Laura L Stockton

Int. Cl.
CPC ...
C07D 235/06 (2006.01); C07D 235/24 (2006.01); C07D 295/125 (2006.01); C07D 401/12 (2006.01); C07D 471/04 (2006.01); A61K 45/06 (2006.01); C07D 235/08 (2006.01); A61K 31/4184 (2006.01); A61K 31/5377 (2006.01); A61K 31/454 (2006.01); A61K 31/437 (2006.01); A61K 31/506 (2006.01); A61K 31/497 (2006.01); A61K 31/55 (2006.01); A61K 31/541 (2006.01); A61K 31/439 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 471/08 (2006.01); A61K 31/553 (2006.01); C07D 235/30 (2006.01); C07D 235/14 (2006.01); C07D 401/04 (2006.01); C07D 235/12 (2006.01); A61K 31/444 (2006.01); A61K 31/4545 (2006.01); A61K 31/538 (2006.01); A61K 31/5386 (2006.01); A61K 31/438 (2006.01); C07D 403/12 (2006.01); A61K 31/4439 (2006.01); C07D 413/12 (2006.01); A61K 31/496 (2006.01); C07D 487/04 (2006.01); A61K 31/4725 (2006.01); C07D 235/28 (2006.01); C07D 235/16 (2006.01); C07D 409/12 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 31/4184 (2013.01); A61K 31/437 (2013.01); A61K 31/438 (2013.01); A61K 31/439 (2013.01); A61K 31/444 (2013.01); A61K 31/4439 (2013.01); A61K 31/454 (2013.01); A61K 31/4545 (2013.01); A61K 31/4725 (2013.01); A61K 31/496 (2013.01); A61K 31/497 (2013.01); A61K 31/506 (2013.01); A61K 31/538 (2013.01); A61K 31/5377 (2013.01); A61K 31/5386 (2013.01); A61K 31/541 (2013.01); A61K 31/55 (2013.01); A61K 31/553 (2013.01); A61K 45/06 (2013.01); C07D 235/06 (2013.01); C07D 235/08 (2013.01); C07D 235/12 (2013.01); C07D 235/14 (2013.01); C07D 235/16 (2013.01); C07D 235/24 (2013.01); C07D 235/28 (2013.01); C07D 235/30 (2013.01); C07D 295/125 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/12 (2013.01); C07D 413/12 (2013.01); C07D 471/08 (2013.01); C07D 487/04 (2013.01);
Abstract

The present disclosure provides indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors of Formula I: or pharmaceutically acceptable salts thereof, in which X, L, n, m, R, R, R, R, R, and Rare as defined herein, as well as pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts thereof, and methods of using the same to treat conditions mediated by IDO1.

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