The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 24, 2018
Filed:
Dec. 15, 2016
Applicant:
Universitetet I Oslo, Blindern, NO;
Inventors:
Kjetil Tasken, Rykkinn, NO;
Birgitte Lygren, Kolbotn, NO;
Ellen Ostensen, Lillestrom, NO;
Jo Klaveness, Oslo, NO;
Assignee:
UNIVERSITETET I OSLO, Blindern, NO;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 307/81 (2006.01); C07D 213/36 (2006.01); C07C 211/43 (2006.01); C07D 277/28 (2006.01); C07C 217/58 (2006.01); C07C 229/38 (2006.01); C07C 211/49 (2006.01); C07D 257/04 (2006.01); C07C 211/27 (2006.01); C07C 275/40 (2006.01);
U.S. Cl.
CPC ...
C07D 307/81 (2013.01); C07C 211/27 (2013.01); C07C 211/43 (2013.01); C07C 211/49 (2013.01); C07C 217/58 (2013.01); C07C 229/38 (2013.01); C07C 275/40 (2013.01); C07D 213/36 (2013.01); C07D 257/04 (2013.01); C07D 277/28 (2013.01);
Abstract
The present invention relates to tertiary amines of formula (I) for use in therapy, particularly for use in treating cardiovascular disorders. The compounds have been found to regulate phospholamban phosphorylation by interfering with the A-kinase anchor protein 18delta (AKAP18δ) binding to the PKA substrate phospholamban. The compounds share a tri(alkylaryl/alkylheteroaryl) amine structure.