The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 24, 2018
Filed:
Jul. 07, 2017
Applicants:
Children's Hospital Medical Center, Cincinnati, OH (US);
University of Cincinnati, Cincinnati, OH (US);
Inventors:
Yi Zheng, Cincinnati, OH (US);
Matthew Wortman, Ft Wright, KY (US);
Assignees:
Children's Hospital Medical Center, Cincinnati, OH (US);
Univeristy of Cincinnati, Cincinnati, OH (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 231/36 (2006.01); A61K 31/4152 (2006.01); A61K 31/498 (2006.01); C07D 403/06 (2006.01); C12Q 1/34 (2006.01);
U.S. Cl.
CPC ...
C07D 231/36 (2013.01); A61K 31/4152 (2013.01); A61K 31/498 (2013.01); C07D 403/06 (2013.01); C12Q 1/34 (2013.01); G01N 2500/00 (2013.01);
Abstract
Provided are inhibitors of Rho GTPase activation, and, in particular, compounds that inhibit RhoA activation by an RhoGEF. Also provided are related pharmaceutical compositions and methods. Also provided are methods of inhibiting Rho GTPase activation. Also provided are methods of screening for compounds that inhibit Rho GTPase activation by a RhoGEF.