The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 24, 2018
Filed:
Feb. 16, 2017
Tacurion, Bridgewater, NJ (US);
Souichirou Kawazoe, Tokyo, JP;
Takahiro Akiba, Tokyo, JP;
Kiichi Sato, Tokyo, JP;
Akio Miyafuji, Tokyo, JP;
Kazuyoshi Obitsu, Tokyo, JP;
Junji Itoh, Tokyo, JP;
Shun Hirasawa, Tokyo, JP;
Hiroyuki Koshio, Tokyo, JP;
TACURION, Bridgewater, NJ (US);
Abstract
The present invention provides a method for producing a 4,4,7-trifluoro-1,2,3,4-tetrahydro-5H-1-benzazepine compound which has an superior agonistic activity to an arginine vasopressin V2 receptor and is useful as an active ingredient for a pharmaceutical composition for preventing and/or treating urinary frequency, urinary incontinence, enuresis, central diabetes insipidus, nocturia, nocturnal enuresis, or the like; and useful intermediates for use in the methods. The production method of the present invention is suitable for the industrial production of a medicament, because of a smaller number of steps, a higher yield, and a lower cost, as compared with the methods in the related art.