The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 24, 2018
Filed:
Jun. 19, 2015
Applicants:
Bioalliance C.v., Alkmaar, NL;
Abgenomics International Inc., Dover, DE (US);
Inventors:
Rong-Hwa Lin, Palo Alto, CA (US);
Shih-Yao Lin, Taipei, TW;
Yu-Chi Hsieh, New Taipei, TW;
Chiu-Chen Huang, Taipei, TW;
Shu-Hua Lee, Taipei, TW;
Yu-Ying Tsai, Taipei, TW;
Feng-Lin Chiang, Taipei, TW;
Li-An Hu, Taipei, TW;
Assignees:
BIOALLIANCE C.V., Alkmaar, NL;
ABGENOMICS INTERNATIONAL INC., Dover, DE (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/48 (2006.01); C07K 16/28 (2006.01); A61K 31/427 (2006.01); A61K 47/68 (2017.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/48561 (2013.01); A61K 31/427 (2013.01); A61K 47/6803 (2017.08); A61K 47/6849 (2017.08); A61K 47/6889 (2017.08); C07K 16/28 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/52 (2013.01); C07K 2317/73 (2013.01);
Abstract
The present disclosure provides anti-folate receptor alpha (FRA) antibody-drug conjugates comprising a hydrophilic self-immolative linker. The present disclosures further provide compositions and methods for treating cancers.