The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 24, 2018
Filed:
Jul. 06, 2015
Applicants:
Karl Edwin Griswold, Lyme, NH (US);
Thomas Carr Scanlon, Lebanon, NH (US);
Inventors:
Karl Edwin Griswold, Lyme, NH (US);
Thomas Carr Scanlon, Lebanon, NH (US);
Assignee:
Other;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/21 (2006.01); C12N 9/36 (2006.01); A61K 39/00 (2006.01); A61K 38/47 (2006.01);
U.S. Cl.
CPC ...
A61K 38/47 (2013.01); C12N 9/2462 (2013.01); C12Y 302/01017 (2013.01);
Abstract
The present invention is a genetically engineered version of a lysozyme protein wherein the engineered enzyme exhibits enhanced antimicrodial activity, relative to the wild type enzyme, as a result of a reduced overall electrostatic charge. Such an enzyme is an attractive therapeutic candidate for treating microbial or viral infections, particularly in cases where the infection results in an accumulation of polyanion inhibitors at the site of infection. Respiratory tract infections are one example of an infection where such an enzyme might be a particularly useful drug.