The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 24, 2018
Filed:
Nov. 14, 2012
Applicant:
Duke University, Durham, NC (US);
Inventors:
Kenneth W. Lyles, Durham, NC (US);
Cathleen S. Colon-Emeric, Durham, NC (US);
Christopher M. O'Connor, Durham, NC (US);
Dennis Abraham, Durham, NC (US);
Kent Nilsson, Athens, GA (US);
Howard Rockman, Durham, NC (US);
Graham Russell, Durham, NC (US);
Assignee:
DUKE UNIVERSITY, Durham, NC (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/675 (2006.01); A61K 45/06 (2006.01); A61K 31/663 (2006.01); A61K 31/592 (2006.01); A61K 31/593 (2006.01); A61K 31/662 (2006.01);
U.S. Cl.
CPC ...
A61K 31/675 (2013.01); A61K 31/592 (2013.01); A61K 31/593 (2013.01); A61K 31/662 (2013.01); A61K 31/663 (2013.01); A61K 45/06 (2013.01);
Abstract
The present invention provides for methods and compositions for treating, reducing and/or preventing cardiac dysfunction by administering to subject a therapeutically effective amount of a bisphosphonate, prodrug thereof, functional analog or a pharmaceutically effective salt thereof in an amount sufficient to increase activity of at least one kinase in heart tissue of the subject.