The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 24, 2018
Filed:
Dec. 19, 2016
Vitae Pharmaceuticals, Inc., Fort Washington, PA (US);
Yuri Bukhtiyarov, Boothwyn, PA (US);
Salvacion Cacatian, Conshohocken, PA (US);
Lawrence Wayne Dillard, Yardley, PA (US);
Cornelia Dorner-Ciossek, Ingelheim am Rhein, DE;
Klaus Fuchs, Ingelheim am Rhein, DE;
Lanqi Jia, Horsham, PA (US);
Deepak S. Lala, Lower Gwynedd, PA (US);
Angel Morales-Ramos, Blue Bell, PA (US);
Jonathan Reeves, Ridgefield, CT (US);
Suresh B. Singh, Kendall Park, NJ (US);
Shankar Venkatraman, Landsdale, PA (US);
Zhenrong Xu, Chalfont, PA (US);
Jing Yuan, Lansdale, PA (US);
Yi Zhao, Blue Bell, PA (US);
Yajun Zheng, Hockessin, DE (US);
Georg Rast, Ingelheim am Rheim, DE;
Vitae Pharmaceuticals, Inc., Madison, NJ (US);
Abstract
The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates.