The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 24, 2018
Filed:
Jun. 17, 2015
Acerta Pharma B.v., Oss, NL;
Ahmed Hamdy, Santa Cruz, CA (US);
Wayne Rothbaum, Delray Beach, FL (US);
Raquel Izumi, San Carlos, CA (US);
Brian Lannutti, Solana Beach, CA (US);
Todd Covey, San Carlos, CA (US);
Roger Ulrich, Sammamish, WA (US);
Dave Johnson, Aptos, CA (US);
Tjeerd Barf, Ravenstein, NL;
Allard Kaptein, Zaltbommel, NL;
Acerta Pharma B.V., Oss, NL;
Abstract
Therapeutic combinations of a Janus kinase-2 (JAK-2) inhibitor, a Bruton's tyrosine kinase (BTK) inhibitor, and/or a phosphoinositide 3-kinase (PI3K) inhibitor, including PI3K inhibitors selective for the γ- and δ-isoforms and selective for both γ- and δ-isoforms, are described. In some embodiments, the invention provides pharmaceutical compositions comprising combinations of (1) a PI3K-δ inhibitor and a BTK inhibitor, (2) a JAK-2 inhibitor and a BTK inhibitor, or (3) a JAK-2 inhibitor, PI3K-δ inhibitor, and BTK inhibitor, and methods of using the pharmaceutical compositions for treating a disease, in particular a cancer.