The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 17, 2018
Filed:
Jul. 03, 2012
Jason Flora, Richmond, VA (US);
Barbara K. Zedler, Richmond, VA (US);
Edward Lenn Murrelle, Midlothian, VA (US);
Mark Leppert, Salt Lake City, UT (US);
Edwin J. C. G. Van Den Oord, Richmond, VA (US);
Bradley Todd Webb, Richmond, VA (US);
Timothy York, Richmond, VA (US);
Gaurav S. J. B. Rana, Richmond, VA (US);
Jeffrey S. Edmiston, Mechanicsville, VA (US);
Willie J. Mckinney, Richmond, VA (US);
Jason Flora, Richmond, VA (US);
Barbara K. Zedler, Richmond, VA (US);
Edward Lenn Murrelle, Midlothian, VA (US);
Mark Leppert, Salt Lake City, UT (US);
Edwin J. C. G. van den Oord, Richmond, VA (US);
Bradley Todd Webb, Richmond, VA (US);
Timothy York, Richmond, VA (US);
Gaurav S. J. B. Rana, Richmond, VA (US);
Jeffrey S. Edmiston, Mechanicsville, VA (US);
Willie J. McKinney, Richmond, VA (US);
Lineagen, Inc., Salt Lake City, UT (US);
Abstract
Cigarette smoking is a primary determinant of chronic obstructive pulmonary disease (COPD), which is the fourth leading cause of morbidity and mortality in the United States. Unique proteins associated with COPD capable of differentiating subjects likely to experience rapid (RPD) or slow (SLW) decline in lung function have been identified using comprehensive high-throughput proteomic approaches. Thirty peptides, which mapped to 21 unique proteins, were linearly associated with annualized rates of lung function decline among smokers with COPD characterized as having rapid or slow decline and smokers without COPD. Using three different statistical approaches to assess the data, the RPD and SLW groups are differentiated by 55 peptides, which mapped to 33 unique proteins. A number of the identified peptides are proteolytic fragments of proteins that are involved in the complement and/or coagulation systems, have anti-protease activity, or metabolic functions.