The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 17, 2018

Filed:

Jul. 07, 2014
Applicants:

Kyowa Medex Co., Ltd., Tokyo, JP;

Kyoto University, Kyoto, JP;

Inventors:

Noriyuki Ogawa, Shizuoka, JP;

Fumi Umehara, Shizuoka, JP;

Takehide Kimura, Tokyo, JP;

Kousaku Murata, Kyoto, JP;

Wataru Hashimoto, Kyoto, JP;

Assignees:

KYOWA MEDEX CO., LTD., Tokyo, JP;

KYOTO UNIVERSITY, Kyoto, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 19/02 (2006.01); C12Q 1/26 (2006.01); G01N 33/72 (2006.01); C12N 9/04 (2006.01); C12N 9/06 (2006.01); C12Q 1/37 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/26 (2013.01); C12N 9/0006 (2013.01); C12N 9/0032 (2013.01); C12Q 1/37 (2013.01); G01N 33/723 (2013.01); G01N 33/725 (2013.01); C12Y 105/03 (2013.01); G01N 2333/805 (2013.01); G01N 2333/90672 (2013.01); G01N 2333/952 (2013.01);
Abstract

The present invention provides a protein comprising an amino acid sequence in which arginine at position 61 of a protein comprising the amino acid sequence represented by SEQ ID NO: 1 is substituted to an amino acid selected from the group consisting of glycine, alanine, valine, leucine, serine, threonine, proline, cysteine, methionine, asparagine, glutamine, and aspartic acid; and a method for measuring a glycated hemoglobin in a sample, wherein the method comprises reacting a glycated hemoglobin in a sample with a protease to produce a glycated hexapeptide, then reacting the produced glycated hexapeptide with the aforementioned protein, and measuring a substance produced or consumed by the reaction.


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