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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9944935 B1

PDFFull Text
Date of Patent:
Apr. 17, 2018

Filed:

Apr. 20, 2016

Methods to improve vector expression and genetic stability

Applicant:

International Aids Vaccine Initiative, New York, NY (US);

Inventors:

Christopher L. Parks, Boonton, NJ (US);

Kevin J. Wright, Brooklyn, NY (US);

Maoli Yuan, Brooklyn, NY (US);

Christy K. Jurgens, Rahway, NJ (US);

Xinsheng Zhang, Merrick, NY (US);

Arban Domi, Parsippany, NJ (US);

Simon Hoffenberg, Hartsdale, NY (US);

Maria J. Chiuchiolo, Brooklyn, NY (US);

Svetlana Rabinovich, Staten Island, NY (US);

Aaron J. Wilson, Brooklyn, NY (US);

Ivo C. Lorenz, Brooklyn, NY (US);

Assignee:

INTERNATIONAL AIDS VACCINE INITIATIVE, New York, NY (US);

Attorneys:

Vedder Price P.C.

Thomas J. Kowalski

Deborah L. Lu

Primary Examiner:

Nancy J Leith

Int. Cl.
CPC ...
C12N 15/67 (2006.01); C12N 15/68 (2006.01); C07K 14/005 (2006.01); A61K 39/12 (2006.01); C12N 7/00 (2006.01); C12N 15/86 (2006.01); C12N 15/64 (2006.01); C12P 21/02 (2006.01); A61K 39/21 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/68 (2013.01); A61K 39/12 (2013.01); C07K 14/005 (2013.01); C12N 7/00 (2013.01); C12N 15/67 (2013.01); C12N 15/86 (2013.01); A61K 39/21 (2013.01); A61K 2039/5254 (2013.01); A61K 2039/5256 (2013.01); C12N 2740/16122 (2013.01); C12N 2740/16134 (2013.01); C12N 2760/16034 (2013.01); C12N 2760/18443 (2013.01); C12N 2760/20243 (2013.01);
Abstract

The present invention relates to methods of developing gene inserts that are more compatible with the host vectors by modifying a protein sequence to lessen potential interference with vector propagation while ensuring that the protein is expressed and processed efficiently and maintains desired structural features, and designing a gene with a nucleotide sequence that resembles the base composition of the host vector genome.

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