The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 17, 2018
Filed:
Oct. 29, 2015
Applicants:
Ospedale San Raffaele S.r.l., Milan, IT;
Fondazione Telethon, Rome, IT;
Inventors:
Assignee:
OSPEDALE SAN RAFFAELE S.R.L., Milan, IT;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/0783 (2010.01); C12N 5/0784 (2010.01); A61K 35/17 (2015.01); A01N 63/02 (2006.01); C12N 5/071 (2010.01); A61K 35/12 (2015.01);
U.S. Cl.
CPC ...
C12N 5/0637 (2013.01); A61K 35/17 (2013.01); C12N 5/064 (2013.01); C12N 5/0636 (2013.01); A61K 2035/122 (2013.01); A61K 2035/124 (2013.01); C12N 2501/22 (2013.01); C12N 2501/23 (2013.01); C12N 2501/231 (2013.01); C12N 2502/1121 (2013.01); C12N 2506/115 (2013.01);
Abstract
The present invention relates to a tolerogenic dendritic cell population (Tr-DC) capable of generating a population of T cells having regulatory activity, method of production and uses thereof. Furthermore, soluble HLA-G promotes the differentiation of a population of T cells with regulatory activity.