The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 17, 2018
Filed:
Dec. 02, 2015
Applicant:
General Electric Company, Schenectady, NY (US);
Inventors:
Brian Michael Davis, Albany, NY (US);
Kenneth Roger Conway, Clifton Park, NY (US);
Evelina Roxana Loghin, Rexford, NY (US);
Xiaohua Zhang, Niskayuna, NY (US);
Assignee:
GENERAL ELECTRIC COMPANY, Schenectady, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); C12M 1/00 (2006.01); C12M 3/06 (2006.01); C12M 1/26 (2006.01); C12M 1/33 (2006.01); C12M 1/36 (2006.01); C12N 5/0735 (2010.01); C12N 5/074 (2010.01);
U.S. Cl.
CPC ...
C12M 29/10 (2013.01); C12M 27/16 (2013.01); C12M 33/14 (2013.01); C12M 33/22 (2013.01); C12M 41/48 (2013.01); C12M 45/02 (2013.01); C12M 47/00 (2013.01); C12M 47/02 (2013.01); C12N 5/0606 (2013.01); C12N 5/0607 (2013.01);
Abstract
Provided herein are novel methods for expansion and passaging of cell aggregates comprising stem cells and/or differentiated cells and comprising the use of closed systems on rocking platform bioreactors. The methods of the invention permit closed system serial passage expansion of pluripotent stem cells and/or progeny thereof with associated pluripotency markers and differentiation potential.