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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9944708 B1

PDFFull Text
Expired
Date of Patent:
Apr. 17, 2018

Filed:

Nov. 25, 2014

Site-specific antibody-mediated activation of proapoptotic cytokines: amaize (antibody-mediated apoptosis inducing cytokines)

Applicant:

Biontech Ag, Mainz, DE;

Inventors:

Klaus Pfizenmaier, Tiefenbronn, DE;

Harald Wajant, Kist, GB;

Dieter Moosmayer, Berlin, DE;

Thomas Wuest, Dietikon, CH;

Assignee:

BioNTech AG, Mainz, DE;

Attorney:

Schwegman Lundberg & Woessner, P.A.

Primary Examiner:

Misook Yu

Assistant Examiner:

Anne L Holleran

Int. Cl.
CPC ...
C07K 19/00 (2006.01); A61K 47/42 (2017.01); A61K 38/19 (2006.01); C07K 16/28 (2006.01); B82Y 5/00 (2011.01); C07K 14/525 (2006.01); C07K 14/705 (2006.01); A61K 47/68 (2017.01); C07K 16/30 (2006.01); C07K 14/715 (2006.01); C07K 7/04 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2866 (2013.01); A61K 47/6899 (2017.08); B82Y 5/00 (2013.01); C07K 14/525 (2013.01); C07K 14/70575 (2013.01); C07K 2319/00 (2013.01);
Abstract

Subject matter of the invention are antibody-cytokine fusion proteins having proapoptotic and immune modulating properties, but wherein the cytokine moiety a priori has a bioactivity which is very low or restricted to certain receptor subtypes. These reagent exert their full biological activity via the corresponding cytokine receptor(s) only after antibody-mediated binding of the fusion protein to a specific cell membrane-expressed target molecule. By suitable choice of the antibody specificity, the cytokine activity is directed to the tissue, e.g. tumour tissue, to be treated, and a therapeutic agent can be produced being specifically designed/optimised for the respective indication/tumour entity.

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Pfizenmaier, Klaus. (2018). Site-specific antibody-mediated activation of proapoptotic cytokines: amaize (antibody-mediated apoptosis inducing cytokines) (U.S. Patent No. 9944708). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9944708

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