The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 17, 2018
Filed:
Dec. 04, 2014
Hangzhou Minsheng Institutes for Pharma Research Co., Ltd, Hangzhou, Zhejiang, CN;
Hangzhou Yuanchang Medical Sci-tech Co., Ltd, Hangzhou, Zhejiang, CN;
Yaodong Wu, Zhejiang, CN;
Jiaqi Shan, Zhejiang, CN;
Ximing Shen, Zhejiang, CN;
Chunxia Wu, Zhejiang, CN;
Binnan Huang, Zhejiang, CN;
HANGZHOU YUANCHANG MEDICAL SCI-TECH CO., LTD, Hangzhou, Zhejiang, CN;
HANGZHOU MINSHENG INSTITUTES FOR PHARMA RESEARCH CO., LTD, Hangzhou, Zhejiang, CN;
Abstract
The invention provides gemcitabine derivatives shown in the following formula (I) and preparation methods thereof. The invention further relates to a pharmaceutical composition which comprising the said gemcitabine derivatives in an effective amount and a pharmaceutically acceptable excipient or additive. The invention further provides use of the said derivatives for preparing anti-tumor drugs. The compound designed by the invention is novel in structure and has a remarkable anti-tumor activity. According to the compound designed by the invention, the preparation starting materials have extensive sources and are easily obtained, the preparation method is simple and easy to operate, and the yield of the product is high, so that industrial production on a large scale is facilitated.