The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 17, 2018
Filed:
Jan. 07, 2014
Peter Caravan, Cambridge, MA (US);
Eric M. Gale, Charlestown, MA (US);
Galen S. Loving, Charlestown, MA (US);
Shereya Mukherjee, Charlestown, MA (US);
Jiang Zhu, Charlestown, MA (US);
Peter Caravan, Cambridge, MA (US);
Eric M. Gale, Charlestown, MA (US);
Galen S. Loving, Charlestown, MA (US);
Shereya Mukherjee, Charlestown, MA (US);
Jiang Zhu, Charlestown, MA (US);
The General Hospital Corporation, Boston, MA (US);
Abstract
Manganese coordination complexes with utility as magnetic resonance probes and as biological reductant sensors are disclosed. In one embodiment, ligands can stabilize both the Mnand Mnoxidation states. In the presence of a reductant such as glutathione, low relaxivity Mn-HBET is rapidly converted to high relaxivity Mn-HBET with a 3-fold increase in relaxivity, and concomitant increase in magnetic resonance signal. In another embodiment, ligands were designed to chelate Mn(ll) in a thermodynamically stable and kinetically inert fashion while allowing for direct interaction of Mn(ll) with water. In yet another embodiment, high molecular weight multimers containing six Mn(ll) chelators were prepared. The high molecular weight results in slower tumbling of the molecules in solution and can strongly enhance the Mn(ll) relaxivity.