IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9944620 B1

PDFFull Text
Date of Patent:
Apr. 17, 2018

Filed:

Jul. 22, 2014

Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them

Applicants:

Les Laboratoires Servier, Suresnes, FR;

Vernalis (R&d) Ltd, Winnersh, GB;

Inventors:

Arnaud Le Tiran, Croissy sur Seine, FR;

Thierry Le Diguarher, Sanit Denis de l'Hôtel, FR;

Jéròme-Benoît Starck, Rueil-Malmaison, FR;

Jean-Michel Henlin, Suresnes, FR;

Guillaume De Nanteuil, Suresnes, FR;

Olivier Geneste, Rueil-Malmaison, FR;

James Edward Paul Davidson, Great Shelford, GB;

James Brooke Murray, Linton, GB;

I-Jen Chen, Cambridge, GB;

Assignees:

LES LABORATOIRES SERVIER, Suresnes, FR;

VERNALIS (R&D) LTD, Winnersh Berkshire, GB;

Attorney:

Hueschen and Sage

Primary Examiner:

Niloofar Rahmani

Int. Cl.
CPC ...
C07D 401/14 (2006.01); C07D 471/04 (2006.01); A61K 31/4985 (2006.01); C07D 487/04 (2006.01); C07D 519/00 (2006.01); A61K 45/06 (2006.01); A61K 31/4725 (2006.01); A61K 31/475 (2006.01); A61K 31/5377 (2006.01); A61K 9/20 (2006.01); A61K 31/4709 (2006.01); A61N 5/10 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); A61K 9/2018 (2013.01); A61K 9/2054 (2013.01); A61K 9/2059 (2013.01); A61K 31/475 (2013.01); A61K 31/4709 (2013.01); A61K 31/4725 (2013.01); A61K 31/4985 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); A61N 5/10 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 519/00 (2013.01);
Abstract

Compounds of formula (I) wherein Ra, Rb, Rc, Rd, T, R3, R4, R5, X, Y and Het are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.

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