The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 17, 2018
Filed:
Sep. 16, 2014
Glen E. Kellogg, Ashland, VA (US);
Chenxiao Da, Chapel Hill, NC (US);
Ashutosh Tripathi, Bryan, TX (US);
John T. Gupton, Midlothian, VA (US);
Nakul Telang, Richmond, VA (US);
James A. Sikorski, Chesterfield, MO (US);
Susan L. Mooberry, San Antonio, TX (US);
Cristina Rohena, San Antonio, TX (US);
Glen E. Kellogg, Ashland, VA (US);
Chenxiao Da, Chapel Hill, NC (US);
Ashutosh Tripathi, Bryan, TX (US);
John T. Gupton, Midlothian, VA (US);
Nakul Telang, Richmond, VA (US);
James A. Sikorski, Chesterfield, MO (US);
Susan L. Mooberry, San Antonio, TX (US);
Cristina Rohena, San Antonio, TX (US);
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US);
VIRGINIA COMMONWEALTH UNIVERSITY, Richmond, VA (US);
UNIVERSITY OF RICHMOND, Richmond, VA (US);
Abstract
The present invention provides polysubstituted pyrrole compounds, pharmaceutically effective salts, prodrugs, solvates and hydrates thereof, having antimitotic, antiproliferative and cytotoxic activity, activity against cells expressing the drug efflux protein, P-glycoprotein, or cells expressing the β-III isotype of tubulin and antitumor activity. Also provided are methods of utilizing these compounds for inhibiting the proliferation of cancer cells as well as their medical use, in particular for treating cancer, including drug resistant cancer.