The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 17, 2018

Filed:

Dec. 21, 2012
Applicants:

Herlev Hospital, Herlev, DK;

Aarhus Universitet, Aarhus C, DK;

Inventors:

Karen Julie Gehl, Vanløse, DK;

Stine Krog Frandsen, Frederiksberg C, DK;

Jens Ole Eriksen, Værløse, DK;

Hanne Margrethe Gissel Hyldkrog, Trige, DK;

Pernille Højman Jensen, København S, DK;

Assignee:

HERLEV HOSPITAL, Herlev, DK;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61B 17/20 (2006.01); A61K 41/00 (2006.01); A61K 33/14 (2006.01); A61K 45/06 (2006.01); A61K 38/14 (2006.01); A61K 33/06 (2006.01); A61K 31/7064 (2006.01); A61M 5/14 (2006.01); A61M 37/00 (2006.01); A61N 1/32 (2006.01);
U.S. Cl.
CPC ...
A61K 41/0047 (2013.01); A61K 31/7064 (2013.01); A61K 33/06 (2013.01); A61K 33/14 (2013.01); A61K 38/14 (2013.01); A61K 41/0033 (2013.01); A61K 45/06 (2013.01); A61M 5/14 (2013.01); A61M 37/0092 (2013.01); A61N 1/327 (2013.01); A61M 2037/0007 (2013.01); A61M 2202/049 (2013.01); A61M 2250/00 (2013.01);
Abstract

The present inventors have shown that electroporation with calcium ions are efficient on cutaneous and subcutaneous nodules. In particular the present inventors here disclose that a solution comprising calcium ions (Ca) with a concentration of at least 0.1 M is extremely useful in a method of treating a neoplasm, such as cancer with means for causing transient permeabilization of the cell membranes of at least part of the neoplasm before, during and/or after administration of said solution, wherein said solution is administered with a ratio of 0.2 to 0.8 of the volume of said part of the neoplasm.


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