The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 17, 2018
Filed:
Jun. 16, 2014
Cornell University, Ithaca, NY (US);
University of Maryland, Baltimore, Baltimore, MD (US);
Ari Melnick, New York, NY (US);
Leandro Carlos A. Cerchietti, New York, NY (US);
Mariano G. Cardenas, New York, NY (US);
Fengtian Xue, New York, NY (US);
Alexander D. MacKerell, Baltimore, MD (US);
Cornell University, Ithaca, NY (US);
University of Maryland, Baltimore, Baltimore, MD (US);
Abstract
The invention provides compositions and methods for blocking the BCL6 BTB domain with small molecule, non-peptide compounds as disclosed and claimed herein. BCL6 is a transcriptional repressor of the BTB-POZ (brie a brae, tramtrack, broad complex/pox virus zincfinger) family of proteins. It is required for normal development of germinal center (GC) B-cells and is also the most commonly involvedoncogene in diffuse large B-celllymphomas (DLBCLs), and constitutive expression of BCL6 in GC B-cells causes DLBCL in mice.