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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9943482 B1

PDFFull Text
Date of Patent:
Apr. 17, 2018

Filed:

Feb. 26, 2014

Milk-derived microvesicle compositions and related methods

Applicant:

University of Louisville Research Foundation, Inc., Louisville, KY (US);

Inventors:

Ramesh C. Gupta, Prospect, KY (US);

Radha Munagala, Louisville, KY (US);

Farrukh Aqil, Louisville, KY (US);

Jeyaprakash Jeyabalan, Louisville, KY (US);

Assignee:

University of Louisville Research Foundation, Inc., Louisville, KY (US);

Attorneys:

Law Office of JL Simunic

Joan Simunic

Primary Examiner:

Amy H Bowman

Int. Cl.
CPC ...
C07H 21/02 (2006.01); C07H 21/04 (2006.01); A61K 9/127 (2006.01); A61K 31/704 (2006.01); A61K 31/7042 (2006.01); A61K 9/00 (2006.01); A61K 9/51 (2006.01); A61K 31/12 (2006.01); A61K 31/337 (2006.01); A61K 31/343 (2006.01); A61K 31/352 (2006.01); A61K 31/585 (2006.01); A61K 31/7048 (2006.01); A61K 31/7105 (2006.01);
U.S. Cl.
CPC ...
A61K 9/1276 (2013.01); A61K 9/0019 (2013.01); A61K 9/0043 (2013.01); A61K 9/0053 (2013.01); A61K 9/5176 (2013.01); A61K 31/12 (2013.01); A61K 31/337 (2013.01); A61K 31/343 (2013.01); A61K 31/352 (2013.01); A61K 31/585 (2013.01); A61K 31/704 (2013.01); A61K 31/7042 (2013.01); A61K 31/7048 (2013.01); A61K 31/7105 (2013.01);
Abstract

A composition is provided that comprises a therapeutic agent encapsulated by a milk-derived microvesicle. The compositions can include therapeutic agents such as phytochemical agents or chemotherapeutic agents, while the milk-derived microvesicle can be derived from raw milk or colostrum. Further provided are methods for isolating a microvesicle that includes the steps of obtaining an amount of milk, and subjecting the milk to a series of sequential centrifugations configured to yield greater than about 300 mg of microvesicle protein per 100 ml of milk. Methods of modifying an immune response and treating a cancer in which a milk-derived microvesicle composition is administered are also provided.

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Gupta, Ramesh. (2018). Milk-derived microvesicle compositions and related methods (U.S. Patent No. 9943482). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9943482

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