The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 10, 2018
Filed:
May. 02, 2014
Children's Medical Center Corporation, Boston, MA (US);
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Richard I. Gregory, Brookline, MA (US);
Elena Piskounova, Dallas, TX (US);
Dimitrios Iliopoulos, Los Angeles, CA (US);
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
Children's Medical Center Corporation, Boston, MA (US);
Abstract
The present embodiments provide for compositions and methods that regulate microRNA-binding protein-mediated miRNA biogenesis; for example Lin28-mediated biogenesis of let-7; and in particular Lin28A-recruited 3' terminal uridylyl transferase (TUTase) uridylation of pre-let-7. A particular embodiment provide compositions and methods for screening for agents that inhibit TUTase-dependent Lin28A-mediated repression of let-7 miRNA.