The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 10, 2018
Filed:
Nov. 05, 2015
Applicant:
Novartis Ag, Basel, CH;
Inventors:
Jan Grunewald, San Diego, CA (US);
Yunho Jin, San Diego, CA (US);
Weijia Ou, San Diego, CA (US);
Tetsuo Uno, San Diego, CA (US);
Assignee:
Novartis AG, Basel, CH;
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); C07K 7/64 (2006.01); C07K 16/22 (2006.01); C07K 16/30 (2006.01);
U.S. Cl.
CPC ...
C07K 7/64 (2013.01); C07K 16/22 (2013.01); C07K 16/30 (2013.01); C07K 2319/30 (2013.01);
Abstract
The invention disclosed herein relates to cytotoxic cyclic peptides of Formula (I), methods of inhibiting RNA polymerase with such cyclic peptides, immunoconjugates comprising such cyclic peptides (i.e Antibody Drug Conjugates), pharmaceutical compositions comprising such cyclic peptides immunoconjugates, compositions comprising such cyclic peptides immunoconjugates with a therapeutic co-agent and methods of treatment using such cyclic peptides immunoconjugates: