The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 10, 2018

Filed:

Nov. 15, 2013
Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Abdelghani Abe Achab, Melrose, MA (US);

Michael D. Altman, Needham, MA (US);

Yongqi Deng, Newton, MA (US);

Solomon Kattar, Wakefield, MA (US);

Jason D. Katz, Newton, MA (US);

Joey L. Methot, Westwood, MA (US);

Hua Zhou, Acton, MA (US);

Meredeth McGowan, Boston, MA (US);

Matthew P. Christopher, Brookline, MA (US);

Yudith Garcia, Brookline, MA (US);

Neville John Anthony, Northborough, MA (US);

Francesc Xavier Fradera Llinas, Brookline, MA (US);

Liping Yang, Arlington, MA (US);

Changwei Mu, Beijing, CN;

Xiaona Wang, Beijing, CN;

Feng Shi, Beijing, CN;

Baijun Ye, Beijing, CN;

Sixing Zhang, Beijing, CN;

Xiaoli Zhao, Beijing, CN;

Rong Zhang, Beijing, CN;

Kin Chiu Fong, Beijing, CN;

Xiansheng Leng, Beijing, CN;

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/52 (2006.01); A61K 31/535 (2006.01); C07D 473/00 (2006.01); C07D 403/00 (2006.01); C07D 487/04 (2006.01); C07D 473/34 (2006.01); A61K 45/06 (2006.01); A61K 31/5377 (2006.01); A61K 31/55 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/52 (2013.01); A61K 31/5377 (2013.01); A61K 31/55 (2013.01); A61K 45/06 (2013.01); C07D 473/34 (2013.01); C07D 519/00 (2013.01);
Abstract

The instant invention provides compounds of formula I which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases such as inflammation, asthma, COPD and cancer.


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