The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 10, 2018
Filed:
Feb. 13, 2015
Applicant:
Idorsia Pharmaceuticals Ltd, Allschwil, CH;
Inventors:
Assignee:
IDORSIA PHARMACEUTICALS LTD, Allschwil, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 239/56 (2006.01); C07D 401/12 (2006.01); C07D 239/34 (2006.01);
U.S. Cl.
CPC ...
C07D 239/56 (2013.01); C07D 239/34 (2013.01); C07D 401/12 (2013.01);
Abstract
The invention relates to a process for manufacturing the compound of formula I wherein R is H, (C-C)alkyl or benzyl, or a salt thereof, said process comprising the reaction of the compound of formula I-1 wherein X is Br, Cl or F, or a salt thereof, with the compound of formula I-2 wherein R is H, (C-C)alkyl or benzyl, or a salt thereof, in the presence of a base, and, when X is Br or Cl, in the presence of tetra-n-butyl ammonium fluoride hydrate or cesium fluoride. The invention further relates to the compound of formula I-1 and uses thereof.