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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9937279 B1

PDFFull Text
Date of Patent:
Apr. 10, 2018

Filed:

Nov. 17, 2015

Bone substitute nanocomposites and methods of synthesis using multiphosphorylated peptides

Applicant:

University of Pittsburgh—of the Commonwealth System of Higher Education, Pittsburgh, PA (US);

Inventors:

Elia Beniash, Pittsburgh, PA (US);

Charles S. Sfeir, Pittsburgh, PA (US);

Assignee:

University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US);

Attorneys:

Eckert Seamans Cherin & Mellott, LLC

Carol A. Marmo

Primary Examiner:

Elizabeth C Kemmerer

Int. Cl.
CPC ...
A61K 38/10 (2006.01); A61K 38/16 (2006.01); C01F 5/00 (2006.01); A61L 27/28 (2006.01); A61L 27/22 (2006.01); C07K 14/47 (2006.01); C07K 7/08 (2006.01); A61L 27/46 (2006.01); A61L 27/54 (2006.01); A61L 27/24 (2006.01); A61L 27/48 (2006.01); C07K 14/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61L 27/227 (2013.01); A61L 27/24 (2013.01); A61L 27/46 (2013.01); A61L 27/48 (2013.01); A61L 27/54 (2013.01); C07K 7/08 (2013.01); C07K 14/001 (2013.01); C07K 14/47 (2013.01); A61K 38/00 (2013.01); A61L 2300/25 (2013.01); A61L 2300/252 (2013.01); A61L 2430/02 (2013.01);
Abstract

The invention relates to peptides including DEDE(SSD)DEG indicated by SEQ NO. 1, RRRDEDE(SSD)DEG indicated by SEQ NO. 2, RRRGDEDE(SSD)DEG indicated by SEQ NO. 3, and LKKLKKLDEDE(SSD)nDEG indicated by SEQ NO. 4, wherein n is an integer from 2 to 20. The invention also relates to phosphorylating these peptides at multiple amino acid sites by employing casein kinases. These phosphorylated peptides may be used in various applications such as forming mineralized collagen fibrils and biomimetic composites for use in tissue repair and regeneration.

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Beniash, Elia. (2018). Bone substitute nanocomposites and methods of synthesis using multiphosphorylated peptides (U.S. Patent No. 9937279). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9937279

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