The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 10, 2018
Filed:
Mar. 10, 2015
Applicant:
Icahn School of Medicine AT Mount Sinai, New York, NY (US);
Inventors:
Michael Ohlmeyer, Plainsboro, NJ (US);
David Kastrinsky, Fair Lawn, NJ (US);
Assignee:
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, New York, NY (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/517 (2006.01); A61K 31/55 (2006.01); A61K 31/18 (2006.01); C07C 311/29 (2006.01); C07D 243/38 (2006.01); C07D 471/04 (2006.01); C07D 265/38 (2006.01); C07D 267/18 (2006.01); C07D 495/04 (2006.01); C07D 209/86 (2006.01); C07D 487/04 (2006.01);
U.S. Cl.
CPC ...
A61K 31/55 (2013.01); A61K 31/18 (2013.01); A61K 31/517 (2013.01); C07C 311/29 (2013.01); C07D 209/86 (2013.01); C07D 243/38 (2013.01); C07D 265/38 (2013.01); C07D 267/18 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 495/04 (2013.01); C07C 2601/08 (2017.05); C07C 2601/14 (2017.05); C07C 2603/18 (2017.05);
Abstract
A genus of arylsulfonamide derivatives of aminocycloalkanols is disclosed. The compounds are of the following genus: The compounds induce FOXO1 transcription factor translocation to the nucleus by modulating PP2A and, as a consequence, exhibit anti-proliferative effects. They are useful in the treatment of a variety of disorders, including as a monotherapy in cancer treatment, or used in combination with other drugs to restore sensitivity to chemotherapy where resistance has developed.