The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 03, 2018
Filed:
Jul. 07, 2011
Applicant:
Hening Lin, New York, NY (US);
Inventor:
Hening Lin, New York, NY (US);
Assignee:
CORNELL UNIVERSITY, Ithaca, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/37 (2006.01); A61K 31/197 (2006.01); C12Q 1/25 (2006.01); C12Q 1/34 (2006.01); C07D 239/56 (2006.01); C07D 233/70 (2006.01); C07D 233/80 (2006.01); C07D 233/84 (2006.01); C07D 233/90 (2006.01); C07D 235/04 (2006.01); C07D 401/06 (2006.01); C07D 405/06 (2006.01); C07D 409/04 (2006.01); C07D 239/70 (2006.01); C07D 243/04 (2006.01); C07D 471/04 (2006.01); C07D 491/052 (2006.01); C07D 495/04 (2006.01); C07D 513/04 (2006.01); C07D 285/24 (2006.01); C07K 7/06 (2006.01); C07K 14/47 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/37 (2013.01); A61K 31/197 (2013.01); C07D 233/70 (2013.01); C07D 233/80 (2013.01); C07D 233/84 (2013.01); C07D 233/90 (2013.01); C07D 235/04 (2013.01); C07D 239/56 (2013.01); C07D 239/70 (2013.01); C07D 243/04 (2013.01); C07D 285/24 (2013.01); C07D 401/06 (2013.01); C07D 405/06 (2013.01); C07D 409/04 (2013.01); C07D 471/04 (2013.01); C07D 491/052 (2013.01); C07D 495/04 (2013.01); C07D 513/04 (2013.01); C07K 7/06 (2013.01); C07K 14/47 (2013.01); C12Q 1/25 (2013.01); C12Q 1/34 (2013.01); A61K 38/00 (2013.01);
Abstract
Sirt5, a mitochondrial Sirtuin, has been identified herein as an efficient demalonylase and desuccinylase. Disclosed herein are assays to identify Sirt5 modulators based on this robust enzymatic activity. Sirt5-specific modulators can be used study the biological function of Sirt5 and to target Sirt5 activities in treating human diseases.