The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 03, 2018
Filed:
Nov. 02, 2015
Applicant:
Shire Human Genetic Therapies, Inc., Lexington, MA (US);
Inventors:
Paolo Martini, Boston, MA (US);
Michael Concino, Bolton, MA (US);
Assignee:
Shire Human Genetic Therapies, Inc., Lexington, MA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/24 (2006.01); A61K 38/46 (2006.01); C07K 7/08 (2006.01); C07K 14/65 (2006.01); A61K 38/30 (2006.01); A61K 38/47 (2006.01); C07K 14/00 (2006.01); A61K 9/00 (2006.01); A61K 38/00 (2006.01); A61K 47/65 (2017.01);
U.S. Cl.
CPC ...
C12N 9/2402 (2013.01); A61K 38/30 (2013.01); A61K 38/465 (2013.01); A61K 38/47 (2013.01); A61K 47/65 (2017.08); C07K 7/08 (2013.01); C07K 14/00 (2013.01); C07K 14/65 (2013.01); C12Y 302/0105 (2013.01); A61K 9/0019 (2013.01); A61K 38/00 (2013.01); C07K 2319/01 (2013.01); C07K 2319/35 (2013.01); C07K 2319/74 (2013.01);
Abstract
Disclosed herein are novel peptide linkers and polypeptide compositions comprising the linkers (e.g., chimeric polypeptides) and methods of using the polypeptide compositions. The compositions and methods are particularly useful for targeting/delivering a polypeptide or protein of interest (e.g., a therapeutic polypeptide) to a cell, tissue or organ of interest in order to treat various diseases or disorders (e.g., lysosomal storage disorders).