The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 03, 2018
Filed:
Mar. 14, 2017
Sanaria Inc., Rockville, MD (US);
Academisch Ziekenhuis Leiden, ZA Leiden, NL;
Stichting Katholieke Universteit, GA Nijmegen, NL;
Chris J. Janse, Leiden, NL;
Takeshi Annoura, Tokyo, JP;
Shahid M. Khan, Leiden, NL;
Ben Van Schaijk, Nijmegen, NL;
Ivo Hj Ploemen, Nijmegen, NL;
Martijn W. Vos, Nijmegen, NL;
Robert Sauerwein, Nijmegen, NL;
SANARIA INC., Rockville, MD (US);
ACADEMISCH ZIEKENHUIS LEIDEN, Leiden, NL;
STICHTING KATHOLIEKE UNIVERSTEIT, Nijmegen, NL;
Abstract
Disclosed herein are mutant-species parasites that are genetically attenuated (GAP). They retain the ability to infect a host and invade host hepatocytes but subsequently their development is completely arrested within the liver stage ofdevelopment and the parasites do not reach the blood stage of development. Vaccines and pharmaceutical compositions comprising genetically attenuatedsporozoites as well as methods of using the same are likewise provided.